June 21, 2021

Best Supplements and Diets for Migraine Sufferers

Approximately one out of every six Americans struggle with migraine headaches. The statistic is even higher for women, with one in five women reporting a migraine over a 3-month period. (4) Unfortunately, there is no known medical cure for migraines but there are medications that can help in preventing migraines before they start.  While these can be effective they sometimes come with unwanted side effects which is why many people are searching for natural alternatives.  There are many natural ways to prevent and treat migraines such as dietary changes and supplementation.  I personally suffer from migraines and have found some effective ways to stop them right as they are presenting.  I’ll get into that in a few! First, let’s talk about some lifestyle and dietary changes that can help prevent migraines from occurring.

Migraine Risk Factors and Triggers

Risk factors for chronic migraines include:

  • Being either obese or underweight
  • Being female
  • Depression
  • Ineffective acute treatment
  • Overusing migraine medication
  • Stressful life events (22)(12)

Some of the studied trigger factors include:

  • Alcohol
  • Fasting or not eating in time
  • Premenstrual periods in women
  • Sleep disturbances
  • The time after stress when the relaxation or “letdown” occurs
  • Weather changes, specifically low barometric pressure (21)(26)(30)

Keeping a journal of foods and life events that seem to trigger migraines may be helpful as individual causes may vary.

Best Supplements and Diets for Migraine Sufferers

The following supplements have demonstrated effectiveness in supporting the treatment of headaches and migraines:

CBD (Cannibidiol) 

While science is still on the fence about the effectiveness of cbd as it relates to the prevention and treatment of migraines, anecdotally many migraine sufferers sing its praises. This makes sense because Cannibidiol (CBD) is a very powerful anti-inflammatory that crosses the blood brain barrier and can readily affect the central nervous system.  I have personally had amazing results as it relates to acute relief of migraines.  In fact I have felt relief within 20 minutes of the onset of a migraine when taking 40 mg or more of CBD.

Butterbur (Petasites hybridus)

Butterbur is a perennial shrub from the daisy family, Asteraceae, whose root can be used for preventative treatment of migraines. (20) The plant itself contains pyrrolizidine alkaloids (PA), which are known to be hepatotoxic. However, certain butterbur extracts are found to be alkaloid-free and therefore, do not pose the same risks. (2)

Butterbur is well-tolerated and is commonly recommended as an alternative for prophylactic treatment in migraine patients. (1)(8)(13)(19) Studies have shown that supplementing with butterbur root extract can result in a 50% to 68% decrease in frequency of migraines. (1)(8)(13)(19)   Butterbur root extract has been found to be safe for migraine prevention.

Feverfew (Tanacetum parthenium)

Feverfew is a perennial plant native to Europe, North America, and South America. The aerial parts of the plant (leaves, flowers, and stems) are used in herbal supplements. (24) The chemical constituents of the plant include sesquiterpene lactones, flavonoids, and volatile oils. Supplementing with feverfew has been shown to be safe, with only mild adverse effects being reported, such as inflammation of the tongue or oral mucosa. (25)

Feverfew has been shown to be beneficial in the prevention of migraines and may reduce migraine frequency and severity. (9)(29)(7)(23)(28)  Feverfew has daisy-like flowers and commonly grows in gardens or along roadsides.

Magnesium

Magnesium is an abundant mineral required by over 300 enzymes involved in many physiological processes in the body. Magnesium is present in drinking water and in foods such as leafy green vegetables, grains, nuts, and legumes. Food processing and cooking, specifically boiling, can lower the magnesium content in food. Low magnesium status has been linked to adverse clinical outcomes, including diabetes, hypertension, coronary heart disease, osteoporosis, and migraines. (31)

Supplemental magnesium has been shown to reduce the intensity and frequency of migraine attacks as well as improve cerebral blood flow. (27)(32)(16) Further research has shown that intravenous magnesium may decrease acute migraine attacks within 15 minutes to 24 hours following administration. (3)(6)

Vitamin D

2000 IU total per day, minimum 12 weeks 

  • Prophylactic supplementation of 100 μg (4000 IU) per day for 24 weeks decreased the frequency of migraines and number of days with a headache in patients aged 18 to 65 when compared to placebo 
  • Patients with episodic migraines experienced 9 fewer days with migraine compared to 3 fewer days in placebo groups; additionally 29% of patients in the treatment group experienced at least a 50% reduction in number of migraines compared to 3% in placebo 

As you can see there are so many alternative ways to treat and prevent migraines that can be highly effective and actually have an overall benefit on your health. 

References:

  1. Agosti, R., Duke, R. K., Chrubasik, J. E., Chrubasik, S. (2006). Effectiveness of Petasites hybridus preparations in the prophylaxis of migraine: a systematic review. Phytomedicine, 13(9-10), 743-6.
  2. Aydin, A. A., Zerbes, V., Parlar, H., & Letzel, T. (2013). The medical plant butterbur (Petasites): Analytical and physiological (re)view. Journal of Pharmaceutical and Biomedical Analysis, 75, 220-229.
  3. Bigal, M. E., Bordini, C. A., & Speciali, J. G. (2002). Arquivos de Neuro-Psiquiatria, 60(2-B), 406-9.
  4. Burch, R., Rizzoli, P., Loder, E. (2018). The prevalence and impact of migraine and severe headache in the United States: figures and trends from government health studies. Headache, 58(4), 496-505.
  5. Charles, A. (2013). The evolution of a migraine attack – a review of recent evidence. Headache, 53(2), 413-9.
  6. Chiu, H. Y., Yeh, T. H., Huang, Y. C., & Chen, P. Y. (2016). Effects of intravenous and oral magnesium on reducing migraine: a meta-analysis of randomized controlled trials. Pain Physician, 19(1), E97-112.
  7. Diener, H. C., Pfaffenrath, V., Schnitker, J., Friede, M., & Henneicke-von Zepelin, H. H. (2005). Efficacy and safety of 6.25 mg t.i.d. feverfew CO2-extract (MIG-99) in migraine prevention–a randomized, double-blind, multicentre, placebo-controlled study. Cephalalgia, 25(11), 1031-41.
  8. Diener, H. C., Rahlfs, V. W., Danesch, U. (2004). The first placebo-controlled trial of a special butterbur root extract for the prevention of migraine: reanalysis of efficacy criteria. European Neurology, 51(2), 89-97.
  9. Ernst, E., & Pittler, M. H. (2000). The efficacy and safety of feverfew (Tanacetum parthenium L.): an update of a systematic review. Public Health Nutrition, 3(4A), 509-14.
  10. Fenstermacher, N., Levin, M., Ward, T. (2011). Pharmacological prevention of migraine. BMJ, 342, d583.
  11. Headache Classification Committee of the International Headache Society (IHS). (2018). The International Classification of Headache Disorders, 3rd edition. Cephalalgia, 38(1), 1–211.
  12. Gelaye, B., Sacco, S., Brown, W. J., Nitchie, H. L., Ornello, R., & Peterlin, B. L. (2017). Body composition status and the risk of migraine: A meta-analysis. Neurology, 88(19), 1795-1804.
  13. Grossman, W., Schmidramsl, H. (2001). An extract of Petasites hybridus is effective in the prophylaxis of migraine. Alternative Medicine Review, 6(3):303-10.
  14. Gürsoy, A. E., Ertaş, M. (2013). Prophylactic treatment of migraine. Nöropsikiyatri Arşivi, 50(1), S30-S35.
  15. Kelman, L. (2004). The premonitory symptoms (prodrome): a tertiary care study of 893 migraineurs. Headache, 44(9), 865-72.
  16. Köseoglu, E., Talaslioglu, A., Gönül, A. S., & Kula M. (2008). The effects of magnesium prophylaxis in migraine without aura. Magnesium Research, 21(2), 101-8.
  17. Linde, M., Mulleners, W. M., Chronicle, E. P., & McCrory, D. C. (2013). Topiramate for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews, 6, CD010610.
  18. Linde, M., Mulleners, W. M., Chronicle, E. P., & McCrory, D. C. (2013). Valproate (valproic acid or sodium valproate or a combination of the two) for the prophylaxis of episodic migraine in adults. Cochrane Database of Systematic Reviews, 6, CD010611.
  19. Lipton, R. B., Göbel, H., Einhäupl, K. M., Wilks, K., & Mauskop, A. (2004). Petasites hybridus root (butterbur) is an effective preventive treatment for migraine. Neurology, 63(12), 2240-4.
  20. Malone, M., Tsai, G. (2018). The evidence for herbal and botanical remedies, Part 1. The Journal of Family Practice, 67(1), 10-16.
  21. Marmura, M. J. (2018). Triggers, protectors, and predictors in episodic migraine. Current Pain and Headache Reports, 22(12), 81.
  22. May, A., Schulte, L. H. (2016). Chronic migraine: risk factors, mechanisms and treatment. Nature Reviews Neurology, 12(8), 455-64.
  23. Murphy, J. J., Heptinstall, S., & Mitchell, J. R. (1988). Randomised double-blind placebo-controlled trial of feverfew in migraine prevention. Lancet, 2(8604), 189-92.
  24. National Institutes of Health (NIH). (2016). Feverfew. Retrieved from: https://nccih.nih.gov/health/feverfew
  25. Pareek, A., Suthar, M., Rathore, G. S., & Bansal, V. (2011). Feverfew (Tanacetum parthenium L.): a systematic review. Pharmacognosy reviews, 5(9), 103–110.
  26. Park, J. W., Chu, M. K., Kim, J. M., Park, S. G., Cho, S. J. (2016). Analysis of trigger factors in episodic migraineurs using a smartphone headache diary applications. PLoS One, 11(2, e0149577.
  27. Peikert, A., Wilimzig, C., & Köhne-Volland, R. (1996). Prophylaxis of migraine with oral magnesium: results from a prospective, multi-center, placebo-controlled and double-blind randomized study. Cephalalgia, 16(4), 257-63.
  28. Pfaffenrath, V., Diener, H. C, Fischer, M., Friede, M., Henneicke-von Zepelin, H. H. (2002). The efficacy and safety of Tanacetum parthenium (feverfew) in migraine prophylaxis–a double-blind, multicentre, randomized placebo-controlled dose-response study. Cephalalgia, 22(7), 523-32.
  29. Saranitzky, E., White, C. M., Baker, E. L., Baker, W. L., & Coleman, C. I. (2009). Feverfew for migraine prophylaxis: a systematic review. Journal of Dietary Supplements, 6(2):91-103.
  30. Spierings, E. L., Donoghue, S., Mian, A., Wöber, C. (2014). Sufficiency and necessity in migraine: how do we figure out if triggers are absolute or partial and, if partial, additive or potentiating? Current Pain and Headache Reports, 18(10), 455.
  31. Swaminathan, R. (2003). Magnesium metabolism and its disorders. Clinical Biochemist Reviews, 24(2), 47–66.
  32. von Luckner, A., & Riederer, F. (2018). Magnesium in migraine prophylaxis- is there an evidence-based rationale? A systematic review. Headache, 58(2),199-209.

 

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